浙江师范大学，化学与生命科学学院，校聘副教授，硕士生导师

Email: wqn1991@zjnu.edu.cn，办公室：7幢410

教育经历

工作经历

研究方向

有机合成方法学研究及其在药物化学中的应用研究；

手性药物活性分子和药物中间体的绿色合成研究及其工艺开发；

主持和参与项目

第68批中国博士后科学基金面上项目，2020M681440，8万，已结题，主持；

国家自然科学基金委重点项目，22031012，300万，在研，参与；

国家自然科学基金面上项目，22071260，63，在研，参与；

发表文章

1. Wang, Q.; Nie, Y.-H.; Liu, C.-X.; Zhang, W.-W.; Wu, Z.-J.; Gu, Q.; Zheng, C.*; You S.-L.* Rhodium(III)-Catalyzed Enantioselective C–H Activation/Annulation of Ferrocenecarboxamides with Internal Alkynes. ACS Catal.2022, 12, 3083-3093.

2. Wang, Q.; Liu, C.-X.; Gu, Q.; You, S.-L.* Chiral Cp^xRh Complexes for C–H Functionalization Reactions. Sci. Bull.2021, 66, 210-213.

3. Lou, J.^†; Wang, Q.^†; Wu, P.^†; Wang, H.*; Zhou, Y.-G.*; Yu, Z.* Transition-metal Mediated Carbon–Sulfur Bond Activation and Transformations: An Update. Chem. Soc. Rev.2020, 49, 4307-4359. (^†Authors contributed equally)

4. Wang, Q.^†; Chen, R.-J.^†; Lou, J.^†; Zhang, D.-H.; Zhou, Y.-G.*; Yu, Z.* Highly Regioselective CH Alkylation of Alkenes Through an Aryl to Vinyl 1,4-Palladium Migration/CC Cleavage Cascade. ACS Catal.2019, 9, 11669-11675. (^†Authors contributed equally)

5. Wang, Q.; Lou, J.; Huang, Z.; Yu, Z.* Rhodium(III)-Catalyzed Annulation of Acetophenone O-Acetyl Oximes with Allenoates through Arene C−H Activation: An Access to Isoquinolines. J. Org. Chem.2019, 84, 2083-2092.

6. Wang, Q.; Liu, Z.; Lou, J.; Yu, Z.* Palladium-Catalyzed C−S Bond Cleavage with Allenoates: Synthesis of Tetrasubstituted 2-Alkenylfuran Derivatives. Org. Lett.2018, 20, 6007-6011.

7. Wang, Q.; Yang, X.; Wu, P.; Yu, Z.* Photoredox-Catalyzed C−H Arylation of Internal Alkenes to Tetrasubstituted Alkenes: Synthesis of Tamoxifen. Org. Lett.2017, 19, 6248-6251.

8. Wang, Q.; Lou, J.; Wu, P.; Wu, K.; Yu, Z.* Iron-Mediated Oxidative C−H Alkylation of S,S-Functionalized Internal Olefins via C(sp²)−H/C(sp³)−H Cross-Coupling. Adv. Synth. Catal.2017, 359, 2981-2998.

9. Lou, J.; Wang, Q.; Zhou, Y.-G.*; Yu, Z.* Rhodium(III)-Catalyzed Annulative Coupling of Sulfoxonium Ylides and Allenoates: An Arene C−H Activation/Cyclopropanation Cascade. Org. Lett.2019, 21, 9217-9222.

10. Lou, J.; Wang, Q.; He, Y.; Yu, Z.* A Simple Aliphatic Diamine Auxiliary for Palladium- Catalyzed Arylation of Unactivated C(sp³)−H Bonds. Adv. Synth. Catal.2018, 360, 4571-4584.

11. Lou, J.; Wang, Q.; Wu, K.; Wu, P.; Yu, Z. * Iron-Catalyzed Oxidative C−H Functionalization of Internal Olefins for the Synthesis of Tetrasubstituted Furans. Org. Lett.2017, 19, 3287-3290.

12. Huang, F.; Liu, Z.; Wang, Q.; Lou, J.; Yu, Z. * Copper-Catalyzed Formal Carbene Migratory Insertion into Internal Olefinic C=C Bonds with N-Tosylhydrazones To Access Iminofuran and 2(3H)-Furanone Derivatives. Org. Lett.2017, 19, 3660-3663.

13. Jiang, Q.; Guo, T..; Gao, R.; Wang, Q.; Lou, J.; Yu, Z.* α,β-Unsaturated N-Acylindoles: An Alternative Class of Michael Acceptors and Their Application in Asymmetric Borylation. J. Org. Chem.2018, 83, 7981-7993.

14. Liu, Z.; Huang, F.; Wu, P.; Wang, Q.; Yu, Z.* Amide Bond Formation Assisted by Vicinal Alkylthio Migration in Enaminones: Metal- and CO-Free Synthesis of α,β-Unsaturated Amides. J. Org. Chem.2018, 83, 5731-5750.

15. Liu, Z.; Huang, F.; Lou, J.; Wang, Q.; Yu, Z.* Copper-Promoted Direct C−H Alkoxylation of S,S-Functionalized Internal Olefins with Alcohols. Org. Biomol. Chem.2017, 15, 5535-5540.

16. Wu, P.; Huang, F.; Lou, J.; Wang, Q.; Liu, Z.; Yu, Z.* Brnsted Acid-Catalyzed Phenylselenenylation of Internal Olefins. Tetrahedron. Lett.2015, 56, 2488-2491.

17. Liu, C.-X.; Zhang, W.-W.; Yang, P.; Zhao, F.; Feng, Z.; Wang, Q. Zhang, S.-Z.; Gu, Q.; You, S.-L.* Pd-catalyzed Asymmetric Oxidative C−H/C−H Cross-Coupling Reaction between Dialkylaminomethylferrocenes and Indolizines. Chem Catal.2022, 2, 102-113.

授权专利

1. 余正坤，汪全南，一种4,4-二烷硫-1-苯基-3-丁烯-1-酮衍生物及其合成方法，2017年，中国发明专利，专利号：ZL201711249062.6。

2. 余正坤，汪全南，吴苹，一种3-烷氧基-1,1-二烷硫基丙烯衍生物及其合成方法，2016年，中国发明专利，专利号：ZL201611102193.7。