植物个体发育始于种子萌发，后经历营养生长期和生殖生长期（开花期）来完成其生命周期。植物营养期由幼年期和成年期组成，幼年期向成年期转变被称为植物营养生长阶段转变。通常，植物只有在完成营养生长期后才能进入生殖生长期。植物营养生长阶段转变调控一系列重要的生理生化及代谢过程，如调控生殖生长、生物量、植物株型、植物次级代谢产物的合成、对生物与非生物胁迫的响应，以及植物不定根形成等。

      吴刚博士的前期研究表明，植物幼年向成年阶段转变主要受miR156-SPL这一年龄信号途径所调控（Wu et al., Cell, 2009）。目前，吴刚博士主要以拟南芥、番茄和黄瓜等植物为研究对象，借助植物遗传学、分子生物学、生物化学及基因组学的方法，继续探索外界环境因子及内在调控因子调控植物miR156-SPL这一年龄信号通路的分子机制，解析年龄依赖型重要性状形成的分子机理，并探讨这些年龄依赖型性状在植物分子育种上应用。

      近年来发表的代表性论文如下（*通讯作者）：

1. Shengjun Feng, Qing Luo, Lu Zhang, Shanshan Zhao, Liang Wei, Yanghui Shen, Yue Wang, Zhantai Lin, Xinyin Wang, Menghao Wang, Baogang Zhang, Zhengpeng Wei, Shuai Gao, Jianguo Wu*,Gang Wu* Control of iron homeostasis by aging in plants.Nature Communications (2026，in revision)

2. Xiang Wang*, Huaiqi Miao, Yixuan Huang, Youwei Wang, Ziyuan Ding, Nanyi Li,Gang Wu*. Natural variation inCYCLIC NUCLEOTIDE-GATED ION CHANNEL 16 controls fruit weight in tomato.Plant Biotechnology Journal (2026, in revision)

3. Xiang Wang, Xia Song, Huaiqi Miao, Shengjun Feng*,Gang Wu*. Natural variation inCYCLIC NUCLEOTIDE-GATED ION CHANNEL 4 reveals a novel role of calcium signaling in vegetative phase change inArabidopsis.New Phytologist (2024) doi: 10.1111/nph.19498

4. Xiang Wang*, Huaiqi Miao, Caijia Lv, andGang Wu*. Genome-wide association study identifies a novelBMI1A QTL allele that confersFLC expression diversity inArabidopsis thaliana.Journal of Experimental Botany(2024) 75(3):837–849

5. Bingying Zhou, Qing Luo, Yanghui Shen, Liang Wei, Xia Song, Hangqian Liao, Lan Ni,Tao Shen，Xinglin Du，Junyou Han, Mingyi Jiang, Shengjun Feng*,Gang Wu*. Coordinated regulation of vegetative phase change by brassinosteroids and the age pathway inArabidopsis.Nature Communications (2023)14:2608, doi.org/10.1038/s41467-023-38207-z

6. Changkui Guo , Youqi Jiang, Min Shi, Xi Wu,Gang Wu*.ABI5 acts downstream of miR159 to delay vegetative phase change inArabidopsis.New Phytologist (2021) 231: 339–350 doi: 10.1111/nph.17371

7. Yunmin Xu , Zhiyuan Qian, Bingying Zhou,Gang Wu*. Age-dependent heteroblastic development of leaf hairs inArabidopsis.New Phytologist (2019) 224: 741–748 doi: 10.1111/nph.16054

8. Changkui Guo, Yunmin Xu, Min Shi, Yongmin Lai, Xi Wu, Huasen Wang, Zhujun Zhu, R. Scott Poethig*, andGang Wu*. Repression of miR156 by miR159 regulates the timing of the juvenile-to-adult transition inArabidopsis.The Plant Cell (2017)29: 1293–1304

9. Yunmin Xu, Changkui Guo, Bingying Zhou, Chenlong Li, Huasen Wang, Ben Zheng, Han Ding, Zhujun Zhu, Angela Peragine, Yuhai Cui, Scott Poethig, andGang Wu*. Regulation of vegetative phase change by SWI2/SNF2 chromatin remodeling ATPase BRAHMA.Plant Physiology (2016),172: 2416–2428

10. Gang Wu, Mee Yeon Park, Susan R. Conway, Jia-Wei Wang, Detlef Weigel, and R. Scott Poethig*. The sequential action of miR156 and miR172 regulates developmental timing inArabidopsis.Cell(2009)138, 750–759

11. Gang Wu, Wan-ching Lin, Tengbo Huang, R. Scott Poethig , Patricia S. Springer, and Randall A. Kerstetter. KANADI1 regulates adaxial–abaxial polarity inArabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2.PNAS (2008)105 (42) 16392-163

12. Gang Wu, R. Scott Poethig. Temporal regulation of shoot development inArabidopsis thaliana by miR156 and its target SPL3. Development (2006) 133 (18): 3539–3547

Email: wugang@zjnu.edu.cn